Anti-Proliferation Effects of Isorhamnetin on Lung Cancer in Vitro asnd in Vivo

Cancer, which causes significant morbidity and mortality, is a major public health problem around the world. Worldwide lung cancer is one of the most common and malignant diseases. Although there has been rapid development of antitumor research, there are few effective remedies for lung cancer. Cytotoxic chemotherapy is being used to control and treat this disease, but it remains relatively nonselective and highly toxic to normal tissues. Natural products have been utilized as novel compounds for the treatment of many diseases, including cancer, because of their ability to inhibit cancer cell growth and induce apoptosis (Kuo et al., 2010). Plant-derived compounds are known to have curative potential, so that finding some efficient compounds from herbs and plants for curing such disease is absolutely interesting for traditional medicine (Luo et al., 2014). The total flavones of Hippophae rhamnoides have